Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions

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Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions.

New reactions and reagents that allow for multiple bond-forming events per synthetic operation are required to achieve structural complexity and thus value with step-, time-, cost-, and waste-economy. Here we report a new class of reagents that function like tetramethyleneethane (TME), allowing for back-to-back [4 + 2] cycloadditions, thereby amplifying the complexity-increasing benefits of Die...

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ژورنال

عنوان ژورنال: Journal of the American Chemical Society

سال: 2015

ISSN: 0002-7863,1520-5126

DOI: 10.1021/jacs.5b04091